Insulin sensitivity depends on the route of glucose administration.

ABSTRACT:

Aims/hypothesis

The small intestine plays an important role in hepatic and whole-body insulin sensitivity, as shown by bariatric surgery. Our goal was to study whether routes and dose of glucose administration have an acute impact on insulin sensitivity. The primary endpoint of this proof-of-concept study was the difference in insulin-mediated metabolic clearance rate (MCR/I) of glucose between the oral and intravenous routes of glucose administration. Secondary endpoints were differences in insulin effect on proteolysis, ketogenesis, lipolysis and glucagon levels.

Methods

In this parallel cohort study, we administered multiple oral glucose loads to 23 participants (aged between 18 and 65 years) with morbid obesity and with normal or impaired glucose tolerance or type 2 diab

SUBMITTER: Mingrone G 

PROVIDER: S-EPMC7286868 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature