Unknown

Dataset Information

0

Eosinophil function in adipose tissue is regulated by Kruppel-like factor 3 (KLF3).

ABSTRACT: The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis.

SUBMITTER: Knights AJ 

PROVIDER: S-EPMC7286919 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellula  ...[more]

Similar Datasets

Unknown Kruppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice.
| S-EPMC7196664 | biostudies-literature
Unknown KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation.
| S-EPMC7769966 | biostudies-literature
Unknown Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis.
| S-EPMC2423134 | biostudies-literature
Unknown Kruppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3).
| S-EPMC4965555 | biostudies-literature
Unknown Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Kruppel-like factor 3 (KLF3) promotes osteosarcoma progression.
| S-EPMC9161850 | biostudies-literature
Unknown Cardiac Timeless Trans-Organically Regulated by miR-276 in Adipose Tissue Modulates Cardiac Function
| S-EPMC10696634 | biostudies-literature
Unknown Kruppel-like factor 2 regulates endothelial barrier function.
| S-EPMC3095948 | biostudies-literature
Unknown Kruppel-like factor-4 and Kruppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis.
| S-EPMC9643672 | biostudies-literature
Unknown Molecular function of Kruppel-like factor 7 in biology.
| S-EPMC10281879 | biostudies-literature
Unknown Adipose tissue coregulates cognitive function.
| S-EPMC10421051 | biostudies-literature