Aging alters acetylation status in skeletal and cardiac muscles.

ABSTRACT: During aging, organs such as skeletal muscle and heart require sufficient NAD⁺ both as a coenzyme for oxidative-reductive electron transfer and as a substrate for multiple signaling pathways. Sirtuins (SIRTs), a family of NAD⁺-dependent deacetylase, play an important role in regulating mitochondrial homeostasis and antioxidant defense by deacetylating transcription factors and enzymes such as PGC-1α, p65, GCN5, and SOD2. However, age-related DNA damage and increased SASP activate PARP-1 and CD38, the enzymes competing with SIRTs for NAD⁺. Thus, it is important to know how aging alters intracellular NAD⁺ status and NAD⁺-depending enzyme expression in muscles. In this study, we report that the acetylation level of muscle protein pool, as

SUBMITTER: Yeo D 

PROVIDER: S-EPMC7286993 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature