Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues.

ABSTRACT: An increase in the burden of senescent cells in tissues with age contributes to driving aging and the onset of age-related diseases. Genetic and pharmacologic elimination of senescent cells extends both health span and life span in mouse models. Heterochronic parabiosis in mice has been used to identify bloodborne, circulating pro- and anti-geronic factors able to drive or slow aging, respectively. However, whether factors in the circulation also regulate senescence is unknown. Here, we measured the expression of senescence and senescence-associated secretory phenotype (SASP) markers in multiple tissues from 4- to 18-month-old male mice that were either isochronically or heterochronically paired for 2 months. In heterochronic parabionts, the age-dependent increase in senescence and SASP ma

SUBMITTER: Yousefzadeh MJ 

PROVIDER: S-EPMC7286998 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature