Ontology highlight
ABSTRACT:
SUBMITTER: Filfan M
PROVIDER: S-EPMC7287009 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Filfan Madalina M Olaru Andrei A Udristoiu Ion I Margaritescu Claudiu C Petcu Eugen E Hermann Dirk M DM Popa-Wagner Aurel A
GeroScience 20200413 3
Let alone calorie restriction, life span extension in higher organisms has proven to be difficult to achieve using simple drugs. Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. However, younger subjects (< 40 years of age) are infrequently prescribed nor self-medicating with antiaging drugs. Therefore, in the present study, we aimed at assessing the effect of long-term treatment with spermidine given in the ...[more]