Effect of Nitrosative Stress on the S-Nitroso-Proteome of Paracoccidioides brasiliensis.

ABSTRACT: The fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the causative agents of paracoccidioidomycosis (PCM), a systemic mycosis endemic to Latin America. This fungus is considered a facultative intracellular pathogen that is able to survive and replicate inside macrophages. The survival of the fungus during infection depends on its adaptability to various conditions, such as nitrosative/oxidative stress produced by the host immune cells, particularly alveolar macrophages. Currently, there is little knowledge about the Paracoccidioides spp. signaling pathways involved in the fungus evasion mechanism of the host defense response. However, it is known that some of these pathways are triggered by reactive oxygen species and reactive nitrogen species (ROS/R

SUBMITTER: Navarro MV 

PROVIDER: S-EPMC7287035 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature