Prediction of prostate cancer aggressiveness using ¹⁸F-Fluciclovine (FACBC) PET and multisequence multiparametric MRI.

ABSTRACT: The aim of this prospective single-institution clinical trial (NCT02002455) was to evaluate the potential of advanced post-processing methods for ¹⁸F-Fluciclovine PET and multisequence multiparametric MRI in the prediction of prostate cancer (PCa) aggressiveness, defined by Gleason Grade Group (GGG). 21 patients with PCa underwent PET/CT, PET/MRI and MRI before prostatectomy. DWI was post-processed using kurtosis (ADC_k, K), mono- (ADC_m), and biexponential functions (f, D_p, D_f) while Logan plots were used to calculate volume of distribution (V_T). In total, 16 unique PET (V_T, SUV) and MRI derived quantitative parameters were evaluated. Univariate and multivariate analysis were carried out to estimate the potential o

SUBMITTER: Movahedi P 

PROVIDER: S-EPMC7287051 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature