In silico analysis reveals EP300 as a panCancer inhibitor of anti-tumor immune response via metabolic modulation.

ABSTRACT: The tumor immune microenvironment (TIME) of head and neck squamous cell carcinomas (HNSCC) and other solid malignancies is a key determinant of therapy response and prognosis. Among other factors, it is shaped by the tumor mutational burden and defects in DNA repair enzymes. Based on the TCGA database we aimed to define specific, altered genes associated with different TIME types, which might represent new predictive markers or targets for immuno-therapeutic approaches. The HNSCC cohort of the TCGA database was used to define 3 TIME types (immune-activated, immune-suppressed, immune-absent) according to expression of immune-related genes. Mutation frequencies were correlated to the 3 TIME types. Overall survival was best in the immune-activated group. 9 genes were significantly differentia

SUBMITTER: Krupar R 

PROVIDER: S-EPMC7287052 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature