Micellization-induced amplified fluorescence response for highly sensitive detection of heparin in serum.

ABSTRACT: Fluorescence-based assays should be feasible in aqueous media for effectively detecting the biological factors. However, numerous sensors have limited signal transductions and low fluorescence quantum yields due to the ingerently reduced excited state energy of fluorophores in aqueous solution, which reduces their sensitivity. This necessitates a smart sensing approach with an amplified fluorescence response for analytes in aqueous solution. Herein, a new building block which self-assembles in aqueous media, giving a micellar sturcuture with the hydrophobic π-extended conjugated system at the core and hydrophilic groups at the periphery, was devised for the first time. We demonstrated that the aggregated fluorophores in a micelle induce amplified fluorescence quenching, in which the excite

SUBMITTER: Jang YJ 

PROVIDER: S-EPMC7287074 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature