Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study.

ABSTRACT: Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26-28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. G

SUBMITTER: Chia AR 

PROVIDER: S-EPMC7287081 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature