Clinical characteristics and PD-L1 expression in primary lung squamous cell carcinoma: A case series.

ABSTRACT:

Background

Squamous cell lung carcinoma(SCLC), accounts for 20% of lung cancer(LC). The binding of programmed cell death 1(PD-1) to its ligand PD-L1 is a key checkpoint regulator of immune response, and overexpression of the latter leads to immune surveillance escape. This might represent an important oncogenic mechanism, as well as a predictor for immunotherapy treatment success in SCLC.

Methods

A retrospective series of 24 patients with SCLC was included(2009-2013). These patients presented with a single pulmonary lesion and no history of previous cancer. Expression of PD-L1 was evaluated on tumoral biopsies with immunohistochemistry. PD-L1 tumor proportion score(TPS) was considered high when ≥50%. Clinical characteristics regarding diagnosis were reviewed and recorded. Da

SUBMITTER: Fernandez-Trujillo L 

PROVIDER: S-EPMC7287140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature