Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis.

ABSTRACT: Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studied in vitro and in vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional

SUBMITTER: Cormican S 

PROVIDER: S-EPMC7287163 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature