Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison.

ABSTRACT: N-Butylbenzenesulfonamide (NBBS) is a widely used plasticizer and hence there is potential for human exposure via oral routes. This work investigates the toxicokinetic behavior of NBBS in rodents following a single gavage (20, 60, and 200 mg/kg body weight) or multi-day feed administration (500, 1000, and 2000 ppm). In male and female rats following gavage administration, maximum plasma NBBS concentration, C_max, was reached at ≤0.539 h. C_max increased proportionally to the dose. Area under the curve (AUC) increased more than proportionally to the dose and was 4- to 5-fold higher in females than in males. In mice, plasma C_max was reached at ≤0.136 h and increased proportionally to the dose in female mice and more than proportionally to the dose in males. AUC

SUBMITTER: Waidyanatha S 

PROVIDER: S-EPMC7287195 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature