Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria.

ABSTRACT:

Background

Anal precancers and cancers can be detected during screening with high-resolution anoscopy (HRA). The sensitivity of HRA depends on the burden and duration of human papillomavirus (HPV) among those screened as well as anoscopist proficiency, which is highly correlated with prior screening experience. Our objective was to compare the identification and type of HPV and the likelihood of HRA-detected precancer for men who have sex with men (MSM) undergoing their first HRA-screening in Nigeria.

Methods

MSM were recruited from an HIV test-and-treat cohort, TRUST/RV368, into a new anal cancer screening program. Anal swabs obtained during screening underwent Ion Torrent next-generation sequencing using barcoded HPV PCR broad-spectrum primers 5+/6+ to detect up to 161 HPV

SUBMITTER: Nowak RG 

PROVIDER: S-EPMC7287273 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature