Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels.

ABSTRACT: Delayed afterdepolarizations (DADs) and spontaneous depolarizations (SDs) are typically triggered by spontaneous diastolic Ca²⁺ release from the sarcoplasmic reticulum (SR) which is caused by an elevated SR Ca²⁺-ATPase (SERCA) uptake and dysfunctional ryanodine receptors. However, recent studies on the T-box transcription factor gene (TBX5) demonstrated that abnormal depolarizations could occur despite a reduced SERCA uptake. Similar findings have also been reported in experimental or clinical studies of diabetes and heart failure. To investigate the sensitivity of SERCA in the genesis of DADs/SDs as well as its dependence on other Ca²⁺ handling channels, we performed systematic analyses using the Maleckar et al. model. Results showed that the modula

SUBMITTER: Lo ACY 

PROVIDER: S-EPMC7287332 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature