Dataset Information

Coordinated changes across the O₂ transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice.

ABSTRACT: Animals native to the hypoxic and cold environment at high altitude provide an excellent opportunity to elucidate the integrative mechanisms underlying the adaptive evolution and plasticity of complex traits. The capacity for aerobic thermogenesis can be a critical determinant of survival for small mammals at high altitude, but the physiological mechanisms underlying the evolution of this performance trait remain unresolved. We examined this issue by comparing high-altitude deer mice (Peromyscus maniculatus) with low-altitude deer mice and white-footed mice (P. leucopus). Mice were bred in captivity and adults were acclimated to each of four treatments: warm (25°C) normoxia, warm hypoxia (12 kPa O₂), cold (5°C) normoxia or cold hypoxia. Acclimation to hypoxia and/o

SUBMITTER: Tate KB

PROVIDER: S-EPMC7287372 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Coordinated changes across the O₂ transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Coordinated changes across the O2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Coordinated changes across the O₂ transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice.