Project description:Background and aimsBalanced nutrition which can help in maintaining immunity is essential for prevention and management of viral infections. While data regarding nutrition in coronavirus infection (COVID-19) are not available, in this review, we aimed to evaluate evidence from previous clinical trials that studied nutrition-based interventions for viral diseases (with special emphasis on respiratory infections), and summarise our observations.MethodsA systematic search strategy was employed using keywords to search the literature in 3 key medical databases: PubMed®, Web of Science® and SciVerse Scopus®. Studies were considered eligible if they were controlled trials in humans, measuring immunological parameters, on viral and respiratory infections. Clinical trials on vitamins, minerals, nutraceuticals and probiotics were included.ResultsA total of 640 records were identified initially and 22 studies were included from other sources. After excluding duplicates and articles that did not meet the inclusion criteria, 43 studies were obtained (vitamins: 13; minerals: 8; nutraceuticals: 18 and probiotics: 4). Among vitamins, A and D showed a potential benefit, especially in deficient populations. Among trace elements, selenium and zinc have also shown favourable immune-modulatory effects in viral respiratory infections. Several nutraceuticals and probiotics may also have some role in enhancing immune functions. Micronutrients may be beneficial in nutritionally depleted elderly population.ConclusionsWe summaries possible benefits of some vitamins, trace elements, nutraceuticals and probiotics in viral infections. Nutrition principles based on these data could be useful in possible prevention and management of COVID-19.

| S-EPMC7161532 | biostudies-literature

Response by Aragam et al to Letter Regarding Article, "Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery".

Project description: Not available

| S-EPMC6764430 | biostudies-literature

Letter to Sarah Basin et al.

Project description: Not available

| S-EPMC8897965 | biostudies-literature

Response to van Dyck, O'Dell, & Mecca letter to the editor regarding Andrews et al. (2019).

Project description: Not available

| S-EPMC10189864 | biostudies-literature

Response by Luby et al to Letter Regarding Article, "Frequency of Blood-Brain Barrier Disruption Postendovascular Therapy and Multiple Thrombectomy Passes in Acute Ischemic Stroke Patients".

Project description: Not available

| S-EPMC6756991 | biostudies-literature

Letter to the Editor regarding clinical debate concerning treatment of pediatric LGG by Cooney et al.

Project description: Not available

| S-EPMC7516102 | biostudies-literature

Letter regarding the Paper by Pearce et al. Entitled '2013 ETA Guideline: Management of Subclinical Hypothyroidism'.

Project description: Not available

| S-EPMC4109500 | biostudies-literature

Letter to the Editor response: Nygaard et al.

Project description:The article by Nygaard and others (2016) proposes that applying batch correction approaches to microarray data from studies with unbalanced designs may inadvertently exaggerate the differences observed. In seeking to illustrate their point, Nygaard and others (2016) utilized a dataset (GSE61901) from a study we published (Towfic and others, 2014) and showed that one analysis pipeline utilizing the traditional approach to batch correction (ComBat) yielded over 1000 differentially expressed probesets, while an alternative approach proposed by Nygaard and others (2016). (utilizing batch as a fixed effect and averaging technical replicates) recovered 11 differentially expressed probesets.

| S-EPMC5379915 | biostudies-literature

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