Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.

ABSTRACT: The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms may lead to unwanted side-effects. In this paper, we show that piano stool Ru complexes can act as HDAC inhibitors, and variation in the capping arene leads to differences in HDAC isoform selectivity.

SUBMITTER: Cross JM 

PROVIDER: S-EPMC7287671 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature