Site-Specific Effects of Online rTMS during a Working Memory Task in Healthy Older Adults.

ABSTRACT: The process of manipulating information within working memory is central to many cognitive functions, but also declines rapidly in old age. Improving this process could markedly enhance the health-span in older adults. The current pre-registered, randomized and placebo-controlled study tested the potential of online repetitive transcranial magnetic stimulation (rTMS) applied at 5 Hz over the left lateral parietal cortex to enhance working memory manipulation in healthy elderly adults. rTMS was applied, while participants performed a delayed-response alphabetization task with two individually titrated levels of difficulty. Coil placement and stimulation amplitude were calculated from fMRI activation maps combined with electric field modeling on an individual-subject basis in order to standa

SUBMITTER: Beynel L 

PROVIDER: S-EPMC7287855 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature