Enhanced Serum Levels of sFlt1: Impact on Materno-Fetal CMV Transmission.

ABSTRACT: Antenatal Cytomegalovirus infection (CMV) can be associated with severe fetal symptoms and newborn outcome. The current prenatal diagnosis is based on amniocentesis (AC). No reliable biomarker for fetal infection is available. We measured Placenta-derived growth factor (PlGF), and soluble fms-like tyrosine kinase 1 (sFlt1), concentrations in maternal serum and amniotic fluid (AF) in context of maternal CMV primary infection. Blood sampling was carried out at the time of AC for detection of fetal CMV infection. The study cohort was divided into four subcohorts according to the presence or absence of fetal infection and preemptive hyperimmunoglobulin (HIG) treatment during the time interval between diagnosis of the CMV primary infection and AC. The study cohort involved 114 pregnancies. In t

SUBMITTER: Penka L 

PROVIDER: S-EPMC7287861 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature