Preparation of Protein-Peptide-Calcium Phosphate Composites for Controlled Protein Release.

ABSTRACT: Protein-peptide-calcium phosphate composites were developed for achieving sustainable and controlled protein release. Bovine serum albumin (BSA) as a model acidic protein was efficiently encapsulated with basic polypeptides such as polylysine and polyarginine during the precipitation of calcium phosphate (CaP). The prepared composites were fully characterized in terms of their morphologies, crystallinities, and the porosity of their structures, and from these analyses, it was observed that there are no significant differences between the composites. Scanning transmission electron microscopy and energy dispersive X-ray spectroscopy analysis indicated a homogeneous distribution of nitrogen and sulfur, confirming the uniform distribution of BSA and polypeptide in the CaP composite. In vitro r

SUBMITTER: Kato K 

PROVIDER: S-EPMC7287863 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature