Association of Primary Humoral Immunodeficiencies With Psychiatric Disorders and Suicidal Behavior and the Role of Autoimmune Diseases.

ABSTRACT:

Importance

The hypothesis that disrupted immune function is implicated in the pathophysiology of psychiatric disorders and suicide is gaining traction, but the underlying mechanisms are largely unknown. Primary humoral immunodeficiencies (PIDs) are rare deficiencies of the immune system-mainly dysfunction of antibody production-and are associated with adverse health problems, such as recurrent infections and autoimmune diseases.

Objective

To establish whether PIDs that affect antibody function and level are associated with lifetime psychiatric disorders and suicidal behavior and whether this association is explained by the co-occurrence of autoimmune diseases.

Design, setting, and participants

This population- and sibling-based cohort study included more than 14 milli

SUBMITTER: Isung J 

PROVIDER: S-EPMC7287945 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature