A Method to Assess the Relevance of Nanomaterial Dissolution During Reactivity Testing.

ABSTRACT: The reactivity of particle surfaces can be used as a criterion to group nanoforms (NFs) based on similar potential hazard. Since NFs may partially or completely dissolve over the duration of the assays, with the ions themselves inducing a response, reactivity assays commonly measure the additive reactivity of the particles and ions combined. Here, we determine the concentration of ions released over the course of particle testing, and determine the relative contributions of the released ions to the total reactivity measured. We differentiate three classes of reactivity, defined as being A) dominated by particles, B) additive of particles and ions, or C) dominated by ions. We provide examples for each class by analyzing the NF reactivity of Fe2O3, ZnO, CuO, Ag using the ferric reduction abi

SUBMITTER: Peijnenburg WJGM 

PROVIDER: S-EPMC7288060 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature