Electrostatic Interactions Enable Nanoparticle Delivery of the Flavonoid Myricetin.

ABSTRACT: Flavonoids are natural polyphenolic compounds with myriad biological activities and potential as prophylactic and therapeutic agents. However, poor aqueous solubility and low bioavailability have limited the clinical utility of flavonoids, suggesting that drug delivery systems (DDSs) may improve their clinical relevance. Therefore, loading of a representative flavonoid (i.e., myricetin) into a diblock, polymeric nanoparticle carrier (NPC) DDS with a cationic corona and hydrophobic core was investigated. Absorbance and fluorescence spectroscopy results revealed association constants and standard Gibbs free energy values that align with previously reported values (K _a = ∼1-3 × 10⁴ M^-1; ΔG° = -5.4 to -6.0 kcal mol^-1), suggesting that N

SUBMITTER: Sims KR 

PROVIDER: S-EPMC7288370 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature