Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity.

ABSTRACT:

Background

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that affects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side effects and limited efficacy at the chronic stage. Natural products provide a pool of diversity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti-T. cruzi activity of nine alkaloids derived from plants of the family Amaryllidaceae.

Methods

The activity of each alkaloid was assessed by means of an anti-T. cruzi phenotypic assay. We further evaluated the compounds that inhibited parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host ce

SUBMITTER: Martinez-Peinado N 

PROVIDER: S-EPMC7288428 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature