Angiogenesis in mammary Paget disease: histopathological analyses of blood vessel density and angiogenic factors.

ABSTRACT:

Background

We examined the vascularity of mammary Paget disease histologically to confirm the increased blood flow observed previously by clinical imaging. The relationships among blood vessel density (BVD), histopathological parameters of blood flow in the nipple, and the expression of angiogenic factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor A (VEGFA) were examined.

Methods

We calculated the average CD34-positive BVD and podoplanin (D2-40)-positive lymphatic vessel density (LVD) and the proportion of proliferating of endothelial cells in 14 Paget disease, 3 dermatitis biopsy, and 14 age-matched control cases. As a parameter related to blood flow in the nipple, the total CD34-positive blood vessel lumen area relative to the enti

SUBMITTER: Akishima-Fukasawa Y 

PROVIDER: S-EPMC7288480 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature