Lasmiditan mechanism of action - review of a selective 5-HT_1F agonist.

ABSTRACT: Migraine is a leading cause of disability worldwide, but it is still underdiagnosed and undertreated. Research on the pathophysiology of this neurological disease led to the discovery that calcitonin gene-related peptide (CGRP) is a key neuropeptide involved in pain signaling during a migraine attack. CGRP-mediated neuronal sensitization and glutamate-based second- and third-order neuronal signaling may be an important component involved in migraine pain. The activation of several serotonergic receptor subtypes can block the release of CGRP, other neuropeptides, and neurotransmitters, and can relieve the symptoms of migraine. Triptans were the first therapeutics developed for the treatment of migraine, working through serotonin 5-HT_1B/1D receptors. The discovery that the seroton

SUBMITTER: Clemow DB 

PROVIDER: S-EPMC7288483 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature