Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.

ABSTRACT:

Background

Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outcomes, finding inconsistent evidence for specific outcomes.

Methods

Maternal iodine status was estimated from spot urine samples collected at 26-28 weeks' gestation from 6971 mothers in the Born in Bradford birth cohort. Associations with outcomes were examined for both urinary iodine concentration (UIC) and iodine-to-creatinine ratio (I:Cr). Outcomes assessed included customised birthweight (primary outcome), birthweight, small for gestational age (SGA), low bir

SUBMITTER: Snart CJP 

PROVIDER: S-EPMC7288513 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature