A mutation that blocks integrin α₄β₇ activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis.

ABSTRACT:

Background

β₇ integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α₄β₇ binds MAdCAM-1, mediating rolling adhesion of lymphocytes on blood vessel walls when inactive and firm adhesion when activated, thereby controlling two critical steps of lymphocyte homing to the gut. By contrast, integrin α_Eβ₇ mediates the adhesion of lymphocytes to gut epithelial cells by interacting with E-cadherin. Integrin β₇ blocking antibodies have shown efficacy in clinical management of inflammatory bowel disease (IBD); however, fully blocking β₇ function leads to the depletion of colonic regulatory T (Treg) cells and exacerbates d

SUBMITTER: Zhang H 

PROVIDER: S-EPMC7288534 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature