Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy.

ABSTRACT: In recent work, asymmetric conjugate addition reactions to chiral 4-phenyl-N-enoyl-1,3-oxazolidinones have been shown to give different stereochemical outcomes depending on the conditions employed. Through the application of stereodivergent reaction conditions, the total synthesis of (+)-pilosinine and the formal synthesis of (-)-pilosinine has been completed from a single enantiomer of the 1,3-oxazolidi-none auxiliary.

SUBMITTER: Schrank CL 

PROVIDER: S-EPMC7288726 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature