Association of macular disease with long-term use of pentosan polysulfate sodium: findings from a US cohort.

ABSTRACT:

Background/aims

A series at a single clinical centre recently demonstrated an association between the interstitial cystitis drug pentosan polysulfate sodium (PPS) and a vision-threatening pigmentary maculopathy. The aim of this study was to determine if an association exists between PPS use and macular disease in a large national cohort.

Methods

A retrospective, matched cohort study using data from a large US medical claims database from 2002 to 2016 was performed. A total of 3012 and 1604 PPS users were compared with 15 060 and 8017 matched controls at 5 and 7 years, respectively. The primary outcome measures included (1) any new diagnosis of a hereditary or secondary pigmentary maculopathy (atypical maculopathy outcome), and (2) any new diagnosis of dry age-related macular

SUBMITTER: Jain N 

PROVIDER: S-EPMC7288845 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature