Understanding and Resetting Radiation Sensitivity in Rectal Cancer.

ABSTRACT:

Objective

The aim of the study was to explore specific microRNAs (miRs) in rectal cancer that would predict response to radiation and identify target pathways that may be exploited for neoadjuvant therapies.

Summary background data

Chemoradiotherapy (CRT) response is a predictor of survival in rectal cancer. Studies have demonstrated changes in RNA expression correlate with chemoradiation sensitivity across cancers.

Methods

Forty-five rectal cancer patients, partial responders (PR = 18), nonresponders (NR = 13), and complete responders (CR = 14) to CRT, as defined by a tumor regression score, were examined. miRs differentially expressed, using NanoString microArray profiling, were validated with qPCR. We quantified 1 miR and its downstream targets in patient samples.

SUBMITTER: Kelley KA 

PROVIDER: S-EPMC7289057 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature