Quantifying the Acoustic Startle Response in Mice Using Standard Digital Video.

ABSTRACT: The startle response is an unconditional reflex, characterized by the rapid contraction of facial and skeletal muscles, to a sudden and intense startling stimulus. It is an especially useful tool in translational research for its consistency across species, simple neural circuitry, and sensitivity to a variety of experimental manipulations. The rodent acoustic startle response is commonly used to study fundamental properties of the central nervous system, including habituation, sensitization, classical conditioning, fear and anxiety, sensorimotor gating, and drug effects. The rodent startle response is typically assessed in stabilimeter chambers, and while these systems are excellent at measuring startle, they are designed only for this sole purpose. In the present study, we used the Video

SUBMITTER: Pantoni MM 

PROVIDER: S-EPMC7289120 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature