Per- and poly-fluoroalkyl substances and bone mineral density: Results from the Bayesian weighted quantile sum regression.

ABSTRACT: Per- and poly-fluoroalkyl substances (PFAS) are chemicals, detected in 95% of Americans, that induce osteotoxicity and modulate hormones, thereby influencing bone health. Previous studies found associations between individual PFAS and bone mineral density in adults but did not analyze their combined effects.

Objective

To extend weighted quantile sum (WQS) regression to a Bayesian framework (Bayesian extension of the WQS regression [BWQS]) and determine the association between a mixture of serum PFAS and mineral density in lumbar spine, total, and neck femur in 499 adults from the 2013 to 2014 National Health and Nutrition Examination Survey (NHANES).

Methods

We used BWQS to assess the combined association of eight PFAS, as a mixture, with bone mineral density in adults. As se

SUBMITTER: Colicino E 

PROVIDER: S-EPMC7289141 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature