Effect of expanding opioid agonist therapies on the HIV epidemic and mortality in Ukraine: a modelling study.

ABSTRACT:

Background

As HIV incidence and mortality continue to increase in eastern Europe and central Asia, particularly among people who inject drugs (PWID), it is crucial to effectively scale-up opioid agonist therapy (OAT), such as methadone or buprenorphine maintenance therapy, to optimise HIV outcomes. With low OAT coverage among PWID, we did an optimisation assessment using current OAT procurement and allocation, then modelled the effect of increased OAT scale-up on HIV incidence and mortality for 23 administrative regions of Ukraine.

Methods

We developed a linear optimisation model to estimate efficiency gains that could be achieved based on current procurement of OAT. We also developed a dynamic, compartmental population model of HIV transmission that included both injection

SUBMITTER: Tan J 

PROVIDER: S-EPMC7289179 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature