Clinical stage provides useful prognostic information even after pathological stage is known for prostate cancer in the PSA era.

ABSTRACT:

Background

Pathological and clinical stage are associated with prostate cancer-specific survival after prostatectomy. With PSA screening, the post-surgery prognostic utility of clinical stage is debatable in studies seeking to identify new biomarkers. Few studies have investigated clinical stage and lethal prostate cancer association after accounting for pathological stage. We hypothesize that clinical stage provides prognostic information beyond pathological stage in the PSA era.

Methods

Cox regression models tested associations between clinical and pathological stage and lethal prostate cancer among 3,064 participants from the Health Professionals Follow-Up Study and Physicians' Health Study (HPFS/PHS) who underwent prostatectomy. Likelihood ratio tests and c-statistics we

SUBMITTER: Chen MM 

PROVIDER: S-EPMC7289430 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature