Environmental exposures and systemic hypertension are risk factors for decline in lung function.

ABSTRACT:

Background

Chronic lung disease is a leading contributor to the global disease burden; however, beyond tobacco smoke, we do not fully understand what risk factors contribute to lung function decline in low-income and middle-income countries.

Methods

We collected sociodemographic and clinical data in a randomly selected, age-stratified, sex-stratified and site-stratified population-based sample of 3048 adults aged ≥35 years from four resource-poor settings in Peru. We assessed baseline and annual pre-bronchodilator and post-bronchodilator lung function over 3 years. We used linear mixed-effects models to assess biological, socioeconomic and environmental risk factors associated with accelerated lung function decline.

Results

Mean±SD enrolment age was 55.4±12.5 years, 4

SUBMITTER: Miele CH 

PROVIDER: S-EPMC7289445 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature