Duodenal Microbiota in Stunted Undernourished Children with Enteropathy.

ABSTRACT:

Background

Environmental enteric dysfunction (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood undernutrition, a pressing global health problem. Defining the incidence of this disorder, its pathophysiological features, and its contribution to impaired linear and ponderal growth has been hampered by the difficulty in directly sampling the small intestinal mucosa and microbial community (microbiota).

Methods

In this study, among 110 young children (mean age, 18 months) with linear growth stunting who were living in an urban slum in Dhaka, Bangladesh, and had not benefited from a nutritional intervention, we performed endoscopy in 80 children who had biopsy-confirmed EED and available plasma and duodenal samples. We quantified

SUBMITTER: Chen RY 

PROVIDER: S-EPMC7289524 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature