Screening Strategies for a Sustainable Endpoint for Gambiense Sleeping Sickness.

ABSTRACT:

Background

Gambiense human African trypanosomiasis ([gHAT] sleeping sickness) is a vector-borne disease that is typically fatal without treatment. Intensified, mainly medical-based, interventions in endemic areas have reduced the occurrence of gHAT to historically low levels. However, persistent regions, primarily in the Democratic Republic of Congo (DRC), remain a challenge to achieving the World Health Organization's goal of global elimination of transmission (EOT).

Methods

We used stochastic models of gHAT transmission fitted to DRC case data and explored patterns of regional reporting and extinction. The time to EOT at a health zone scale (~100 000 people) and how an absence of reported cases informs about EOT was quantified.

Results

Regional epidemiology and leve

SUBMITTER: Castano MS 

PROVIDER: S-EPMC7289553 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature