The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.

ABSTRACT:

Background

Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood.

Methods

In this systematic review and meta-analysis, we investigated the development of tuberculosis in children closely exposed to a tuberculosis case and followed for incident disease. We restricted our search to cohort studies published between Jan 1, 1998, and April 6, 2018, in MEDLINE, Web of Science, BIOSIS, and Embase electronic databases. Individual-participant data and a pre-specified list of variables were requested from authors of all eligible studies. These included

SUBMITTER: Martinez L 

PROVIDER: S-EPMC7289654 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature