Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats.

ABSTRACT: The opioid epidemic has become a severe public health problem, with approximately 130 opioid-induced deaths occurring each day in the United States. Prescription opioids are responsible for approximately 40% of these deaths. Oxycodone is one of the most commonly abused prescription opioids, but despite its prevalent misuse, the number of preclinical studies investigating oxycodone-seeking behaviors is relatively limited. Furthermore, preclinical oxycodone studies that include female subjects are even more scarce, and it is critical that future work includes both sexes. Additionally, the oral route of administration is one of the most common routes for recreational users, especially in the early stages of drug experimentation. However, currently, only two studies have been published investi

SUBMITTER: Fulenwider HD 

PROVIDER: S-EPMC7289656 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature