Reduced Nhe1 (Na⁺-H⁺ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms.

ABSTRACT: IgE-mediated activation of Nhe1 (Na⁺-H⁺ exchanger-1) induces aortic cell extracellular acidification and promotes cell apoptosis. A pH-sensitive probe pHrodo identified acidic regions at positions of macrophage accumulation, IgE expression, and cell apoptosis in human and mouse abdominal aortic aneurysm (AAA) lesions. Ang II (angiotensin II)-induced AAA in Nhe1-insufficient Apoe^-/-Nhe1^+/- mice and Apoe^-/-Nhe1^+/+ littermates tested Nhe1 activity in experimental AAA, because Nhe1^-/- mice develop ataxia and epileptic-like seizures and die early. Nhe1 insufficiency reduced AAA incidence and size, lesion macrophage and T-cell accumulation, collagen deposition, elastin fragmentation, c

SUBMITTER: Liu CL 

PROVIDER: S-EPMC7289683 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature