Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC7289805 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kumar Sriram S Pearse Alexander A Liu Ying Y Taylor Rebecca E RE
Nature communications 20200611 1
Nucleic acid-based materials enable sub-nanometer precision in self-assembly for fields including biophysics, diagnostics, therapeutics, photonics, and nanofabrication. However, structural DNA nanotechnology has been limited to substantially hydrated media. Transfer to organic solvents commonly used in polymer and peptide synthesis results in the alteration of DNA helical structure or reduced thermal stabilities. Here we demonstrate that gamma-modified peptide nucleic acids (γPNA) can be used to ...[more]