Cell size sets the diameter of the budding yeast contractile ring.

ABSTRACT: The formation and maintenance of subcellular structures and organelles with a well-defined size is a key requirement for cell function, yet our understanding of the underlying size control mechanisms is limited. While budding yeast cell polarization and subsequent assembly of a septin ring at the site of bud formation has been successfully used as a model for biological self-assembly processes, the mechanisms that set the size of the septin ring at the bud neck are unknown. Here, we use live-cell imaging and genetic manipulation of cell volume to show that the septin ring diameter increases with cell volume. This cell-volume-dependence largely accounts for modulations of ring size due to changes in ploidy and genetic manipulation of cell polarization. Our findings suggest that the ring dia

SUBMITTER: Kukhtevich IV 

PROVIDER: S-EPMC7289848 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature