Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism.

ABSTRACT: The high incidence of aneuploidy in the embryo is considered the principal cause for low human fecundity. However, the prevalence of aneuploidy dramatically declines as pregnancy progresses, with the steepest drop occurring as the embryo completes implantation. Despite the fact that the plasticity of the embryo in dealing with aneuploidy is fundamental to normal development, the mechanisms responsible for eliminating aneuploid cells are unclear. Here, using a mouse model of chromosome mosaicism, we show that aneuploid cells are preferentially eliminated from the embryonic lineage in a p53-dependent process involving both autophagy and apoptosis before, during and after implantation. Moreover, we show that diploid cells in mosaic embryos undertake compensatory proliferation during the impla

SUBMITTER: Singla S 

PROVIDER: S-EPMC7290028 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature