The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study.

ABSTRACT:

Background

Outcomes following out of hospital cardiac arrest (OHCA) are poor. The optimal arterial oxygen and carbon dioxide (PaCO₂) levels for managing patients following OHCA are unknown. We hypothesized that abnormalities in arterial oxygenation (PaO₂/FiO₂ ratio or PaO₂) and PaCO₂ would be associated with hospital mortality following OHCA. We hypothesized that PaCO₂ would significantly modify the oxygenation-mortality relationship.

Methods

This was an observational cohort study using data from OHCA survivors admitted to adult critical care units in England, Wales and Northern Ireland from 2011 to 2018. Logistic regression analyses were performed to assess the relationship between hospital mortality and oxyg

SUBMITTER: McGuigan PJ 

PROVIDER: S-EPMC7290139 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature