Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line.

ABSTRACT: The alternative splicing of pre-mRNAs expands a single genetic blueprint to encode multiple, functionally diverse protein isoforms. Viruses have previously been shown to interact with, depend on, and alter host splicing machinery. The consequences, however, incited by viral infection on the global alternative slicing (AS) landscape are under-appreciated. Here, we investigated the transcriptional and alternative splicing profile of neuronal cells infected with a contemporary Puerto Rican Zika virus (ZIKV^PR) isolate, an isolate of the prototypical Ugandan ZIKV (ZIKV^MR), and dengue virus 2 (DENV2). Our analyses revealed that ZIKV^PR induced significantly more differential changes in expressed genes compared to ZIKV^MR or DENV2, despite all three virus

SUBMITTER: Bonenfant G 

PROVIDER: S-EPMC7290316 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature