Modelling Degradation and Replication Kinetics of the Zika Virus In Vitro Infection.

ABSTRACT: Mathematical models of in vitro viral kinetics help us understand and quantify the main determinants underlying the virus-host cell interactions. We aimed to provide a numerical characterization of the Zika virus (ZIKV) in vitro infection kinetics, an arthropod-borne emerging virus that has gained public recognition due to its association with microcephaly in newborns. The mathematical model of in vitro viral infection typically assumes that degradation of extracellular infectious virus proceeds in an exponential manner, that is, each viral particle has the same probability of losing infectivity at any given time. We incubated ZIKV stock in the cell culture media and sampled with high frequency for quantification over the course of 96 h. The data showed a delay in the virus degradation in

SUBMITTER: Bernhauerova V 

PROVIDER: S-EPMC7290367 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature