Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology.

ABSTRACT:

Importance

Social determinants of health, such as income, education, housing quality, and employment, are associated with disparities in Alzheimer disease and health generally, yet these determinants are rarely incorporated within neuropathology research.

Objective

To establish the feasibility of linking neuropathology data to social determinants of health exposures using neighborhood disadvantage metrics (the validated Area Deprivation Index) and to evaluate the association between neighborhood disadvantage and Alzheimer disease-related neuropathology.

Design, setting, and participants

This cross-sectional study consisted of decedents with a known home address who donated their brains to 1 of 2 Alzheimer disease research center brain banks in California and Wisconsin

SUBMITTER: Powell WR 

PROVIDER: S-EPMC7290421 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature