Expression of a novel immune checkpoint B7-H6 ligand in human small cell lung cancer.

ABSTRACT:

Background

B7-H6 is a novel co-stimulatory ligand that is detected in most malignancies. However, the significance of B7-H6 in small cell lung cancer (SCLC) remains unknown.

Methods

B7-H6 expression was analyzed by immunohistochemistry (IHC) in 103 collected SCLC samples, and its association with clinicopathological characteristics and prognosis was analyzed. The 2-year survival rates were also investigated.

Results

B7-H6-positive staining was detected in 58 (56.31%) SCLC cases, and found to be localized mainly in the intracellular space of SCLC. Weak staining in lung tissues was observed in 4 (8%) cases. B7-H6 positive staining was significantly related to tumor-node-metastasis stage (P=0.028), age (P=0.001), and distant metastasis (P=0.033), whereas there was no ass

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7290544 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature